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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T28368 | PF-04859989 HCl | PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 | Others |
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s... | |||
T2150 | Guanfacine hydrochloride | Tenex,Intuniv,Guanfacine | Adrenergic Receptor |
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS. | |||
T7165 | Basmisanil | RG1662,RO5186582 | GABA Receptor |
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro... | |||
T28856 | SSR180711 hydrochloride | SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl | AChR |
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders. | |||
T27462 | GSK-239512 | GSK239512,GSK 239512 | Histamine Receptor |
GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders. | |||
T10499 | H3 receptor-MO-1 | Histamine Receptor | |
H3 receptor-MO-1 is a potent modulator of the histamine H3 receptor (H3 receptor) and can be used to study neurodegeneration and cognitive disorders. | |||
T31079 | CP-810123 | CP 810123,UNII-E6G4550EC4,CP810123 | AChR |
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease. | |||
T0183 | Pramiracetam | CI-879 | Others |
Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the t... | |||
T0426 | Piracetam | UCB-6215 | GluR , iGluR |
Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders. | |||
T23066 | NGD 94-1 | Dopamine Receptor | |
NGD 94-1 is a selective D4 receptor antagonist with an affinity of 3 nM for the D4 receptor and greater than 2 pM for the D1, D2, D3, and D5 receptors.NGD 94-1 can be used in the study of cognitive disorders and other ps... | |||
T28655 | Sabeluzole | R 58735,R58735,R-58735 | Microtubule Associated |
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be... | |||
T14507 | Bay 60-7550 | BAY 607550 | PDE |
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem... | |||
T8451 | Tropanserin | MDL 72422 | 5-HT Receptor |
Tropanserin (MDL 72422) is a 5-hydroxytryptamine receptor antagonist that inhibits 5-HT3 receptor activity.Tropanserin has anxiolytic activity and is used to treat depression and cognitive disorders. | |||
T61278 | Aminopeptidase-IN-1 | Aminopeptidase | |
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders. | |||
T12054L | MK-0249 FA | MK-0249 FA(862309-06-6 Free base) | Histamine Receptor |
MK-0249 FA is an orally active, selective and potent histamine H3 inverse agonist for the study of attention deficit, hyperactivity disorder neurodivergent and cognitive disorders in adults. | |||
T68064 | Elziverine | CaMK | |
Elziverine is an orally available small molecule calmodulin antagonist.Elziverine in vitro treatment inhibited Ca-loading-induced acanthocyte formation in SHRSP, WKY, and Wistar rats in a concentration-dependent manner.E... | |||
T30798 | Cerlapirdine | PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531 | 5-HT Receptor |
Cerlapirdine (PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine is already in clinical development for the treatment of cognitive disorders related to Alzhei... | |||
T26646 | AQW051 | AQ W051,VQW-765,AQW-051 | AChR |
AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac... | |||
T32614 | L-Clausenamide | (-)-Clausenamide | Microtubule Associated |
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t... | |||
T16481 | PF-04995274 | 5-HT Receptor | |
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a... |