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Search Results for " cognitive disorders "

20

Compounds

Cat No. Product Name Synonyms Targets
T28368 PF-04859989 HCl PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 Others
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...
T2150 Guanfacine hydrochloride Tenex,Intuniv,Guanfacine Adrenergic Receptor
Guanfacine hydrochloride (Intuniv) is a centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
T7165 Basmisanil RG1662,RO5186582 GABA Receptor
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro...
T28856 SSR180711 hydrochloride SSR-180711A HCl,SSR-180711C HCl,SR-180711 HCl AChR
SSR180711 hydrochloride (SSR-180711A HCl) is a selective Alpha7 nicotinic acetylcholine partial agonist for the study of neurodegenerative and cognitive disorders.
T27462 GSK-239512 GSK239512,GSK 239512 Histamine Receptor
GSK-239512 is an antagonist of H3 receptor and can be used in studies about the treatment of cognitive dysfunction in neurodegenerative disorders.
T10499 H3 receptor-MO-1 Histamine Receptor
H3 receptor-MO-1 is a potent modulator of the histamine H3 receptor (H3 receptor) and can be used to study neurodegeneration and cognitive disorders.
T31079 CP-810123 CP 810123,UNII-E6G4550EC4,CP810123 AChR
CP-810123 is a new alpha 7 nAChR agonist for the treatment of cognitive impairment associated with psychiatric or neurological disorders such as schizophrenia and Alzheimer's disease.
T0183 Pramiracetam CI-879 Others
Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the t...
T0426 Piracetam UCB-6215 GluR , iGluR
Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.
T23066 NGD 94-1 Dopamine Receptor
NGD 94-1 is a selective D4 receptor antagonist with an affinity of 3 nM for the D4 receptor and greater than 2 pM for the D1, D2, D3, and D5 receptors.NGD 94-1 can be used in the study of cognitive disorders and other ps...
T28655 Sabeluzole R 58735,R58735,R-58735 Microtubule Associated
Sabeluzole (R-58735) has antiepileptic and cognitive enhancing effects, inhibits neurotoxin-induced tau expression and cell death.Sabeluzole is protective against chlordiazepoxide-induced habituation disorders and may be...
T14507 Bay 60-7550 BAY 607550 PDE
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem...
T8451 Tropanserin MDL 72422 5-HT Receptor
Tropanserin (MDL 72422) is a 5-hydroxytryptamine receptor antagonist that inhibits 5-HT3 receptor activity.Tropanserin has anxiolytic activity and is used to treat depression and cognitive disorders.
T61278 Aminopeptidase-IN-1 Aminopeptidase
Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.
T12054L MK-0249 FA MK-0249 FA(862309-06-6 Free base) Histamine Receptor
MK-0249 FA is an orally active, selective and potent histamine H3 inverse agonist for the study of attention deficit, hyperactivity disorder neurodivergent and cognitive disorders in adults.
T68064 Elziverine CaMK
Elziverine is an orally available small molecule calmodulin antagonist.Elziverine in vitro treatment inhibited Ca-loading-induced acanthocyte formation in SHRSP, WKY, and Wistar rats in a concentration-dependent manner.E...
T30798 Cerlapirdine PF05212365,P -05212365,SAM-531,SAM531,PF-05212365,SAM 531,WAY-262,531 5-HT Receptor
Cerlapirdine (PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine is already in clinical development for the treatment of cognitive disorders related to Alzhei...
T26646 AQW051 AQ W051,VQW-765,AQW-051 AChR
AQW051 (VQW-765) is an orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) specific activator that interacts with recombinant human α7-nAChR expression (pKD value 7.56). Alpha7-nachr is considered an attrac...
T32614 L-Clausenamide (-)-Clausenamide Microtubule Associated
L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function. L-Clausenamide inhibits beta-amyloid (Aβ) toxicity and prevents t...
T16481 PF-04995274 5-HT Receptor
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a...
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TargetMol